Eye examination apparatus with cameras and display

ABSTRACT

Disclosed is an eye examination apparatus that can be used in professional settings. The eye examination apparatus has a body having a first eye opening and a second eye opening for a user to see into the eye examination apparatus using two eyes. The eye examination apparatus also has a first camera coupled to the body and positioned to acquire ophthalmic images through the first eye opening, and a second camera coupled to the body and positioned to acquire ophthalmic images through the second eye opening. The eye examination apparatus also has at least one display coupled to the body and positioned to be viewable through the first eye opening and the second eye opening.

RELATED APPLICATION

This patent application claims priority to U.S. provisional patentapplication No. 63/186,983 filed May 11, 2021, and U.S. provisionalpatent application No. 63/209,227 filed Jun. 10, 2021. Both of theseUnited States provisional patent applications are incorporated byreference herein in their entirety.

FIELD OF THE DISCLOSURE

This disclosure relates to eye examination apparatuses for visionassessment and diagnostic purposes.

BACKGROUND

Every year, thousands of people suffer from brain and eye diseases, suchas concussion for example. When a person becomes injured, it is prudentto assess whether the person is suffering from concussion or showing anyother vision impairment symptoms. Portable vision diagnostic devices canhelp assess whether individuals are injured and/or concussed, with aview to treating those that are injured and/or concussed while enablingothers to return to their normal activities.

In underprivileged areas and countries, where access to a specialist iseither difficult or impossible, portable eye exam devices are useful toprovide eye-care and vision assessment options to identify life orvision-threatening diseases that should receive immediate medicalattention from benign eye conditions that are not medical emergencies.Additionally, such convenient eye and vision assessments could helpseniors and physically challenged individuals who face difficultytravelling to a physician's clinic. Eye and vision assessment devicescan facilitate convenient eye examinations from anywhere in the world.They provide a plethora of benefits such as allowing users to get eyeassessments from a doctor of their choice; they reduce dependence ontypical eye examination setups; and they can potentially eliminatetravelling to eye centres or clinics for conventional or complexeye-examinations.

Unfortunately, currently available portable eye-examination devices areeither too bulky or complex to use. Some conventional devices onlyprovide tailored solutions i.e, they identify some specific eyecondition but are not useful for routine eye-checkups and vice versa.Often times it is also found that conventional devices lack an expectedlevel of accuracy. More importantly, they fail to identify severe eyeconditions (ophthalmic eye diseases) and therefore are not reliable.

SUMMARY OF THE DISCLOSURE

Disclosed is an eye examination apparatus that can be used inprofessional settings. The eye examination apparatus has a body having afirst eye opening and a second eye opening for a user to see into theeye examination apparatus using two eyes. The eye examination apparatusalso has a first camera coupled to the body and positioned to acquireophthalmic images through the first eye opening, and a second cameracoupled to the body and positioned to acquire ophthalmic images throughthe second eye opening. The eye examination apparatus also has at leastone display coupled to the body and positioned to be viewable throughthe first eye opening and the second eye opening.

Also disclosed is an eye examination apparatus having a visor with atransparent display such that images displayed on the transparentdisplay are overlaid on a view of an environment that can be seenthrough the visor. The eye examination apparatus also includes a firstcamera assembly configured to acquire ophthalmic images of a first eyeof the user, a second camera assembly configured to acquire ophthalmicimages of a second eye of the user, and a processing unit forcontrolling the transparent display, the first camera assembly and thesecond camera assembly.

Also disclosed is an eye examination apparatus configured to be worn bya user and having a display configured to display images overlaid on aview of an environment. The eye examination apparatus also has at leastone semi-transparent mirror or prism, a first camera configured toacquire ophthalmic images of a first eye of the user via reflection offof the at least one semi-transparent mirror or prism, and a secondcamera configured to acquire ophthalmic images of a second eye of theuser via reflection off of the at least one semi-transparent mirror orprism. The eye examination apparatus also has a processing unit forcontrolling the display, the first camera and the second camera.

Other aspects and features of the present disclosure will becomeapparent, to those ordinarily skilled in the art, upon review of thefollowing description of the various embodiments of the disclosure.

BRIEF DESCRIPTION OF THE DRAWINGS

Embodiments will now be described with reference to the attacheddrawings in which:

FIGS. 1 a to 1 d are perspective views of an eye examination apparatusthat makes use of at least one smartphone;

FIG. 1 e is a schematic of the eye examination apparatus being worn by auser for an eye examination;

FIG. 1 f is a perspective view of the eye examination apparatus equippedwith a smartphone;

FIG. 1 g is a side view of the eye examination apparatus equipped withtwo smartphones for an eye examination;

FIG. 1 h is an exemplary ray diagram for the eye examination apparatusillustrating how a camera captures ophthalmic images during an eyeexamination;

FIG. 1 i is a schematic of the eye examination apparatus equipped withtwo smartphones and at least one condenser lens for funduscopy;

FIG. 1 j is a schematic of the eye examination apparatus equipped withtwo smartphones and a mirror 156 for OCT (Ocular Coherence Tomography);

FIG. 1 k is a schematic of the eye examination apparatus equipped with arefraction apparatus for refraction eye examination;

FIGS. 1 l and 1 m are schematics of the refraction apparatus of FIG. 1k;

FIG. 1 n is a schematic of the wheels of the refraction apparatus ofFIGS. 1 l and 1 m;

FIG. 1 o is a schematic of the eye examination apparatus having a pairof occluders;

FIG. 1 p is a flowchart of a computer-implemented method of performingan eye examination;

FIG. 2 a is a schematic of an eye examination apparatus that can be usedin a professional setting;

FIG. 2 b is a schematic of a sensor module of the eye examinationapparatus of FIG. 2 a;

FIGS. 2 c to 2 f are perspective views of the eye examination apparatusimplemented with a headband;

FIGS. 2 g to 2 l are perspective views of the eye examination apparatusimplemented with a helmet; and

FIGS. 3 a to 3 c are perspective views of another eye examinationapparatus that can be used in a professional setting.

DETAILED DESCRIPTION OF EMBODIMENTS

It should be understood at the outset that although illustrativeimplementations of one or more embodiments of the present disclosure areprovided below, the disclosed systems and/or methods may be implementedusing any number of techniques, whether currently known or in existence.The disclosure should in no way be limited to the illustrativeimplementations, drawings, and techniques illustrated below, includingthe exemplary designs and implementations illustrated and describedherein, but may be modified within the scope of the appended claimsalong with their full scope of equivalents.

Smartphone Embodiment

Referring first to FIGS. 1 a to 1 d , shown are perspective views of aneye examination apparatus 100 that makes use of at least one smartphone.The eye examination apparatus 100 has a closed state (FIG. 1 a ) inwhich a front cartridge 111 and an upper cartridge 110 are disposedwithin the eye examination apparatus 100. The eye examination apparatus100 also has an open state (FIG. 1 c ) in which the front cartridge 111and/or the upper cartridge 110 are slid out or removed from the eyeexamination apparatus 100. The front cartridge 111 and the uppercartridge 110 are each configured to hold a smartphone and are slidablyinsertable into a body of the eye examination apparatus 100. The eyeexamination apparatus 100 has two eye openings 101 and 102.

Referring now to FIG. 1 e , shown is a schematic of the eye examinationapparatus 100 being worn by a user for an eye examination. In someimplementations, as shown in the illustrated example, the eyeexamination apparatus 100 has a headband 112 and 113 for securing theeye examination apparatus 100 to the user. The headband 112 and 113 canfor example include an upper strap 112 and a lower strap 113 bothconfigured to be worn on the head by the user to retain the eyeexamination apparatus 100 in place during the eye examination. Othersecuring means are possible.

In the illustrated example, the front cartridge 111 and the uppercartridge 110 each hold a smartphone (i.e. two smartphones in total) forthe eye examination. As explained in further detail below, having twosmartphones can enable the eye examination of both eyes simultaneously.However, it is noted that an eye examination is possible with a singlesmartphone, for example the smartphone in the front cartridge 111, oralternatively the smartphone in the upper cartridge 110.

Referring now to FIG. 1 f , shown is a perspective view of the eyeexamination apparatus 100 equipped with one smartphone 161. Thesmartphone 161 is placed in the front cartridge 111 and inserted into afront cartridge slot. Once inserted, the front cartridge 111 holds thesmartphone 161 in a predefined position in relation to the body, suchthat a camera 115 of the smartphone 161 is positioned to acquireophthalmic images through the first eye opening 101, and a display 116of the smartphone 161 is viewable through the second eye opening 102.This can enable an eye examination of one eye at a time.

Referring now to FIG. 1 g , shown is a side view of the eye examinationapparatus 100 equipped with two smartphones 161-162 for an eyeexamination. As noted above, two smartphones 161-162 can be utilized toenable an eye examination of both eyes simultaneously. To support this,the eye examination apparatus 100 has a semi-transparent mirror 106coupled to the body. With respect to the user's right eye 171, thesemi-transparent mirror 106 is used to reflect light for a camera 117 ofthe smartphone 162 in the upper cartridge 110 while enabling light topass through for the display of the smartphone 161 in the frontcartridge 111. Conversely, with respect to the user's left eye (notshown), the semi-transparent mirror 106 is used to reflect light for adisplay of the smartphone in the upper cartridge 110 while enablinglight to pass through for the camera of the smartphone 162 in the uppercartridge 110.

Each smartphone 161-162 functions as a DCS (Display Camera Set). In someimplementations, the DCS 161 in the front cartridge 111 is designed as aprimary DCS while the DCS 162 in the upper cartridge 110 is designed asa secondary DCS, although the opposite designation is possible. Thecamera 117 of the secondary DCS 162 and the display 116 of the primaryDCS 161 are used for the user's right eye 171, while the camera 115 ofthe primary DCS 161 and the display (not shown) of the secondary DCS 162are used for the user's left eye (not shown). Therefore, images of theright eye 171 are captured by the camera 117 of the secondary DCS 162through a 90-degree reflection off of the semi-transparent mirror 106,while images of the left eye (not shown) are captured directly by thecamera 115 of the primary DCS 161. Meanwhile, the right eye 171 can seethe display 116 of the primary DCS 161 through the semi-transparentmirror 106, and the left eye (not shown) can see the display (not shown)of the secondary DCS 162 through a 90-degree reflection off of thesemi-transparent mirror 106. In some implementations, the two DCSs161-162 have software that when executed enable the two DCSs 161-162 tooperate in sync and present similar images to the two eyes. In otherimplementations, the two DCSs 161-162 can operate independently and showdifferent images. The two DCSs 161-162 can also present two images thatare designed dichoptically and stereoscopically to present objects orscenes in depth. Other implementations are possible.

In the illustrated example, the upper cartridge 110 is configured toposition the secondary DCS 162 in a top portion of the body of the eyeexamination apparatus 100. In other implementations, a lower cartridge(not shown) is configured to position the secondary DCS 162 in a bottomportion of the body. More generally, the eye examination apparatus 100can have a second coupling for receiving the secondary DCS 162 and forholding the same in a predefined position in relation to the body,whether this predefined position is in the top portion of the body or inthe bottom portion of the body. Operation of the eye examinationapparatus 100 is not dependant on whether the secondary DCS 162 is inthe top portion of the body or in the bottom portion of the body,because reflection off of the semi-transparent mirror 106 is possiblefrom the top portion of the body and the bottom portion of the body.

As used herein, “ophthalmic images” can include eye surface images,eyelid images, optic nerve images, retina images, and/or other imagesrelating to ophthalmology. Generally speaking, to acquire ophthalmicimages using a camera, the camera would be positioned in front of apatient's eye and in line with a visual axis of the eye, or in anotherposition provided that reflection and/or refraction of light (e.g. usinga mirror and/or prism) enables the camera to similarly capture the frontof the patient's eye. In either case, preferably the center of thepatient's retina (i.e. macula and optic nerves) can be captured.

Referring now to FIG. 1 h , shown is an exemplary ray diagram for theeye examination apparatus 100 illustrating how a camera 115 capturesophthalmic images during an eye examination. In some implementations,the eye examination apparatus 100 has a pair of convex lenses 151, forexample but not limited to 50 D, for the first eye opening 101 and thesecond eye opening 102. In some implementations, the eye examinationapparatus 100 also has a second pair of convex lens 152, for example butnot limited to 20 D, for the camera 115 of the first smartphone 161 andthe camera 117 of the second smartphone 162 (not shown). In someimplementations, the convex lenses 151 and 152 provide enoughmagnification to enable a wide range of possibilities for the cameras115 and 117 of the smartphones 161-162, as smartphones may have cameraswith lower resolution than desired. However, for cameras with very highresolution, such magnification can be reduced and maybe even eliminatedin which case the convex lenses 151 and 152 can be omitted. Otherimplementations are possible, for example but not limited to emitting,capturing and analyzing rays of light for ocular coherence tomography.

In some implementations, the eye examination apparatus 100 also has atleast one light emitter 153 positioned to generate infrared or visiblelight out of the first eye opening 101 and the second eye opening 102via reflection off of the semi-transparent mirror 106. In someimplementations, the at least one light emitter 153 includes a firstinfrared emitter positioned to generate infrared light out of the firsteye opening 101 and a second infrared emitter positioned to generateinfrared light out of the second eye opening 102. In someimplementations, infrared light can be used for lighting inside the eyeexamination apparatus 100, the reflection of which being captured byinfrared cameras 115 and 117 on the primary and secondary DCSs 161-162.Using this functionality of the primary and secondary DCSs 161-162, theuser can avoid pupil constriction and take pictures of the back of theeye 171 with an instant flashlight when the cameras 115 and 117 arefocused and the picture of retina is clear. In some implementations, theat least one light emitter 153 is part of the secondary DCS 162,although other implementations are possible in which the at least onelight emitter 153 is part of the first DCS 161 or separate from both theDCSs 161-162.

In the illustrated example, the camera 115 of the primary DCS 161 ispositioned directly in front of the patient's eye 171 and in line with avisual axis of the eye so that the camera 115 can capture a center of aretina (i.e. macula and optic nerves) of the eye 171. In this way, thecamera 115 has line of sight out of the eye opening of the eyeexamination apparatus 100. As used herein, “line of sight” refers to asubstantially straight path without reflection within the eyeexamination apparatus 100, although some amount of refraction may bepossible, for example through the semi-transparent mirror 106 and/or anylenses such as the convex lenses 152. Note that the camera 117 of thesecondary DCS 162 is not positioned directly in front of a patient'seye. Rather, the camera 117 of the secondary DCS 162 is positioned inthe upper cartridge 110, although other positions are possible.Nonetheless, by using the semi-transparent mirror 106, it is possiblefor the camera 117 of the secondary DCS 162 to capture the center of theretina of the patient's other eye. The eye examination apparatus 100enables proper positioning of the primary DCS 161 and the secondary DCS162 to acquire ophthalmic images.

According to the eye examination apparatus 100, it is possible for theuser to have an eye examination performed remotely outside of aclinician's office without specialized equipment by instead using theirown smartphone(s) 161-162. This is an improvement over the currentlyavailable portable eye-examination devices. The eye examinationapparatus 100 does not require any high-end cameras. The eye examinationapparatus 100 is relatively easy to use with one or two smartphones161-162 and therefore may be suitable for use by households, schools,paramedics, etc.

Referring now to FIG. 1 i , shown is a schematic of the eye examinationapparatus 100 equipped with two smartphones 161-162 and at least onecondenser lens 154 for funduscopy. Funduscopy is a type of examinationto check a fundus of an eye 172, including the retina and optic nerve,and often uses magnified or focused light to do so. In the illustratedexample, the condenser lens 154 renders a divergent beam from the lightemitter 153 of the smartphone 162 in the upper cartridge 110 into aparallel beam, which is reflected off of the semi-transparent mirror106, and a second lens 151 condenses the parallel beam into a convergingbeam onto the retina of the eye 172. In alternative implementations, thecondenser lens 154 renders the divergent beam into a converging beamonto the retina in which case the second lens 151 may be omitted. Insome implementations, one or both of the lenses 154 and 151 areadjustable for changing focus and focal distances to adapt to differenteye sizes and anatomical variations. The camera 115 of the smartphone161 in the front cartridge 111 serves as a detector that captures lightreflected from the retina of the eye 172 and passes through thesemi-transparent mirror 106 to reach the camera 115. Thus, a combinationof the two smartphones 161-162, the semi-transparent mirror 106, and theat least one condenser lens 154 enables funduscopy to be performed.

In the illustrated example, the light emitter 153 is from the smartphone162 in the upper cartridge 110 and the camera 115 is from the smartphone161 in the front cartridge 111. Additionally, or alternatively, a lightemitter from the smartphone 161 in the front cartridge 111 and thecamera 117 of the smartphone 162 in the upper cartridge 110 can beutilized. Both implementations are possible simultaneously, which canmake it possible to perform funduscopy for both eyes, or separately.

Referring now to FIG. 1 j , shown is a schematic of the eye examinationapparatus 100 equipped with two smartphones 161-162 and a mirror 156 forOCT (Ocular Coherence Tomography). Optical coherence tomography is animaging technique that uses interferometry to capture high-resolutionimages based on interference of superimposed waves from a reference armand a sample arm. In the illustrated example, a low coherence lightsource 153 a generates low coherence light onto the semi-transparentmirror 106, which functions as a beam splitter. For the reference arm,some of the low coherence light passes through the semi-transparentmirror 106, reflects off of the mirror 156, reflects off of thesemi-transparent mirror 106, and is received by the camera 115 of thesmartphone 161 in the front cartridge 111. For the sample arm, the restof the low coherence light from the low coherence light source 153 areflects off of the semi-transparent mirror 106, reflects off of theretina of the eye 172, passes through the semi-transparent mirror 106,and is received by the camera 115. The camera 115 thus receives areference light wave from the reference arm and a sample light wave fromthe sample arm. The reference light wave and the sample light wave caninterfere constructively (i.e. strengthening in intensity) when in phaseor interfere destructively (i.e. weakening in intensity) when out ofphase. Such interference between the reference light wave and the samplelight wave provides imaging information which can be detected as ananalog interference OCT signal. In some implementations, the camera 115is capable of detecting NIR (Near Infrared Light) to help capture theanalog interference OCT signal.

In some implementations, the sample arm includes a lens 151 to condensethe low coherence light into a converging beam onto the retina of theeye 172. Furthermore, in some implementations, the sample arm includes a2D MEMS (Microelectromechanical) mirror 155 which is an opticalbeam-steering device which provides a lateral scanning of the OCT.Collimated light incidents on a dual-axis galvo-mirrors of the 2D M EMSmirror 155 and is redirected to the lens 151, which operates as atelocentric objective lens. The lens 151 focuses the light onto theretina of the eye 172 and back-reflected light is received by the lens151 and focused back through the semi-transparent mirror 106. In someimplementations, the lens 151 and the 2D MEMS mirror 155 are adjustableto provide variable focus and projection.

In some implementations, the camera 115 samples the analog interferenceOCT signal at equal spectral intervals. Each scan produces depthinformation from the interference pattern by reaction at differentdepths in the form of an A-scan. An A-scan is a one-dimensional image ofthe sample (e.g. retina of the eye 172) at a specific depth. Across-sectional image of the microstructure of the sample can beobtained by integrating multiple A-scans. In some implementations, theanalog interference OCT signal which is captured is converted into adigital signal, and OCT fringe data are then processed locally on thesmartphone or sent to a host computer where signal processing can beperformed.

Referring now to FIG. 1 k , shown is a schematic of the eye examinationapparatus 100 equipped with a refraction apparatus 188 for refractioneye examination. A refraction eye examination is an eye exam thatmeasures a person's prescription for eyeglasses or contact lenses. Therefraction apparatus 188 is an optional accessory that can be attachedto the eye examination apparatus 100 in order to enable refraction eyeexamination and subsequently detached. In some implementations, therefraction apparatus 188 attaches to the eye examination apparatus 100using magnetic pins which are installed at the four corners on the backof the eye examination apparatus 100 and front of the refractionapparatus 188. However, other implementations for attaching therefraction apparatus 188 to the eye examination apparatus 100 arepossible.

Referring now to FIGS. 1 l and 1 m , shown are schematics of therefraction apparatus 188 of FIG. 1 k . The refraction apparatus 188 hasat least two wheels 180 and 181 on each side of the refraction apparatus188, for a total of at least four wheels. In some implementations, eachwheel protrudes from the side, creating a dial 189 for the wheel thatcan be used to turn the wheel. In some implementations, the refractionapparatus 188 has additional wheels (not shown). More wheels may bepresent for further detailed variety of refraction or eye examinationsor treatment delivery.

Referring now to FIG. 1 n , shown is a schematic of the wheels 180 and181 of the refraction apparatus 188 of FIGS. 1 l and 1 m . The firstwheel 181 has spherical convex and concave lenses 183 which are used totest refraction. The second wheel 180 has cylindric convex and concavelenses 182 for astigmatism examination. Color red, green, blue, etc.filters, pinholes, any prisms, occluders, neutral density filters or anyother electronically modified or physically modified or controlledlenses or filters may be used in the wheels 180 and 181.

In the illustrated example, a user can change the lenses or filters onthe wheels 180 and 181 using the dials 189. In other implementations,the lenses or filters on the wheels 180 and 181 can be changedelectronically via one or more actuators, which might be electronicallycoupled to the smartphone 161. In this way, it is possible to change thelenses or filters on the wheels 180 and 181 remotely or using thesmartphone 161. In some implementations, results of the refraction eyeexamination are sent to a host computer for evaluation and/or to orderonline prescription eyeglasses or contact lenses.

The eye examination apparatus 100 described herein can be used toexamine one eye at a time or two eyes at the same time. In someimplementations, the eye examination apparatus 100 is equipped with atleast one occlude, for example a pair of occluders. The occluders can beused selectively block light for an eye that is not being examined.Additionally, or alternatively, the occluders can be used indifferentiating vision impairment. An example of this is described belowwith reference to FIG. 1 o.

Referring now to FIG. 1 o , shown is a schematic of the eye examinationapparatus 100 having a pair of occluders 138. In some implementations,the occluders 138 are optionally provided as additional attachments. Theoccluders 138 can either slide/swipe over the lenses 101 or can beplaced directly on the lenses 101. In some implementations, theoccluders 138 have a plurality of pinholes 139 (for example fifteenpinholes as depicted). The pinholes 139 are configured to eliminatedisorganized refracted light arrays which cause blurred vision innon-neurological eye conditions. More precisely, the pinholes 139 assistin differentiating vision impairment caused by neurological eye diseasessuch as multiple sclerosis, stroke, etc. versus non-neurological eyediseases such as refractive error, dry eye, etc. Moreover, the pinholes139 are useful for testing visual acuity in cycloplegic eyes (state ofthe eye after paralyzing the pupil and lens muscles with specific eyedrops) as they are can effectively reduce the intensity of incominglight.

In some implementations, each occluder 138 is secured in place using apin 140 attached to the front surface of the eye examination apparatus100, which enables it to pivot down when being used. In otherimplementations, the occluders 138 can be placed directly on or fittedover the lenses 101. Other implementations are possible.

In some implementations, the first eye opening 101 and the second eyeopening 102 of the eye examination apparatus 100 are separate openingsas depicted. However, other implementations are possible in which thethe first eye opening 101 and the second eye opening 102 are part of thesame opening, namely a large opening that enables the user to see intothe eye examination apparatus 100 using both eyes. In someimplementations, the eye examination apparatus 100 has a middle wall 109separating a left side for examining the user's left eye from a rightside for examining the user's right eye.

There are many possibilities of the body of the eye examinationapparatus 100. In some implementations, the body includes a plasticmaterial. In specific implementations, the body is generated using a 3Dprinter. The front cartridge 111 and the upper cartridge 110 can also beformed of a plastic material and generated using a 3D printer. Inspecific implementations, a user can use a 3D printer to generate theeye examination apparatus 100 themselves. In other implementations, theeye examination apparatus 100 is produced and distributed to the user bya manufacturer. Note that other materials such as cardboard can be usedinstead of (or in addition to) plastic. Factory produced head-mounteddevices are also possible. Other implementations are possible.

There are many possibilities for securing the eye examination apparatus100 to the user. In some implementations, as described above, the eyeexamination apparatus 100 has a headband 112 and 113 for securing theeye examination apparatus 100 to the user. In other implementations, eyeexamination apparatus 100 is simply held by the user against their face.In some implementations, the eye examination apparatus 100 has a noserest 175, which may help to facilitate the eye examination apparatus 100to properly fit against the user's face. Other implementations arepossible.

Although the illustrated examples focus on a particular type of couplingfor receiving smartphone(s), it is noted that other types of couplingare possible and are within the scope of the disclosure. Any suitablecoupling that is able to receive and hold a smartphone in a predefinedposition such that its camera can acquire ophthalmic images through thefirst eye opening 101 and its display is viewable through the second eyeopening 102 can be employed. Snap-fit implementations and/or otherfixation means are possible without sliding cartridges as depicted.Also, other positions for the couplings are possible. For example, asnoted above, rather than the upper cartridge 110, the eye examinationapparatus 100 could employ a lower cartridge (not shown). Otherimplementations are possible.

Although the illustrated examples utilize the semi-transparent mirror106 for reflection, it is noted that a semi-transparent prism can beutilized instead. It is noted that a semi-transparent prism could causemore refraction than the semi-transparent mirror 106, depending ongeometry of course. It is implementation-specific whether asemi-transparent mirror or prism is utilized. In either case, light isenabled to pass through the semi-transparent mirror or prism, generallywith line or sight, albeit with some amount of refraction. In specificimplementations, as shown in the illustrated examples, asemi-transparent mirror is oriented at 45-degree angle relative to thefirst smartphone and the second smartphone to facilitate reflections,given that the smartphones are orthogonal to one another. However, othergeometries are possible and are within the scope of the disclosure.

Referring now to FIG. 1 p , shown is a flowchart of acomputer-implemented method of performing an eye examination. Thismethod can be executed by at least one processor, for example by aprocessor of one of the smartphones described above in relation to FIGS.1 a to 1 o . In some implementations, the smartphone downloads andexecutes an app to enable the computer-implemented method describedbelow.

At step 1-1, the processor captures, using a camera of the smartphone,images of a first eye of a user. At step 1-2, the processor displays,using a display of the smartphone, images for a second eye of the user.In some implementations, the computer-implemented method is performedwith only one smartphone. This can enable an eye examination of one eyeat a time. In other implementations, the computer-implemented method isperformed with two smartphones, which can enable the eye examination ofboth eyes simultaneously.

In some implementations, as shown at step 1-3, the processor captures,using a camera of a second smartphone, images of the first eye of theuser. In some implementations, as shown at step 1-4, the processordisplays, using a display of the second smartphone, images for thesecond eye of the user. In some implementations, as shown at step 1-5,the processor coordinates the first smartphone and the second smartphoneto enable simultaneous capturing of the images of the first eye and thesecond eye. This can help to facilitate the eye examination of both eyessimultaneously.

In some implementations, the first smartphone and the second smartphoneeach have a wireless capability such as Bluetooth radio or Wificonnections, and coordinating the first smartphone and the secondsmartphone involves pairing (for example using the Bluetooth radios orWifi radios) the first smartphone with the second smartphone to form awireless Bluetooth or Wifi connection, and coordinating the firstsmartphone and the second smartphone using communication over thewireless connection. Other implementations are possible.

In some implementations, the processor stores, in a memory of the firstsmartphone, the images of the first eye and the second eye. In otherimplementations, each smartphone stores its own images that have beenacquired. In some implementations, as shown at step 1-6, the methodinvolves transmitting, using a transmitter of the first smartphone, theimages of the first eye and/or the second eye. The transmitted data canbe sent to a clinician's office for example, such that the data can beassessed or examined by a clinician. In other implementations, eachsmartphone transmits its own data. Other implementations are possible.

According to the computer-implemented method, it is possible for theuser to have an eye examination performed remotely outside of aclinician's office without specialized equipment by instead using theirown smartphone(s). This is an improvement over the currently availableportable eye-examination devices. The eye examination apparatus 100 isrelatively easy to use with one or two smartphones and therefore may besuitable for use by households, schools, paramedics, etc.

In some implementations, AI (Artificial intelligence) and machinelearning systems are adopted to analyze the ophthalmic images in orderto recognize healthy from abnormal eye and visual structures andfunctions. All embodiments described herein can be equipped with thisfunctionality. Use of AI can significantly help health professionals tonarrow down a diagnosis and triage an urgent patient to emergency roomor to a physician's office in a timely manner.

According to another embodiment of the disclosure, there is provided anon-transitory computer readable medium having recorded thereonstatements and instructions that, when executed by at least oneprocessor, implement a method as described herein. The non-transitorycomputer readable medium can for example include an SSD (Solid StateDrive), a hard disk drive, a CD (Compact Disc), a DVD (Digital VideoDisc), a BD (Blu-ray Disc), a memory stick, or any appropriatecombination thereof.

Professional Embodiments

Referring now to FIG. 2 a , shown is a schematic of an eye examinationapparatus 200 that can be used in a professional setting. Unlike the eyeexamination apparatus 100 described with reference to FIGS. 1 a to 1 p ,the eye examination apparatus 200 of FIG. 2 a does not make use ofexisting smartphones, but rather is equipped with its own dedicatedsensor modules 121 and 122 and at least one display 119 and 120. Still,the eye examination apparatus 200 of FIG. 2 a operates using similarprinciples as described above for the eye examination apparatus 100 ofFIGS. 1 a to 1 p.

There are many possibilities for the at least one display 119 and 120.In some implementations, as shown in the illustrated example, the atleast one display 119 and 120 includes high-resolution display screensincluding a first display 119 positioned to be viewable through thefirst eye opening 101 and a second 120 display positioned to be viewablethrough the second eye opening 102. In other implementations, the atleast one display 119 and 120 includes a single display having a leftportion viewable through the first eye opening 101 and a right potionviewable through the second eye opening 102. Each of the displays 119and 120 can be placed on an upper portion in the eye examinationapparatus 200 as shown or on another portion such as the front wall inthe eye examination apparatus 200. Other implementations are possible.

There are many possibilities for the sensor modules 121 and 122. Withreference to FIG. 2 b , each sensor module can for example include apair of infrared or visible light projectors/sensors 123 and 124, atleast one high resolution camera 125, and a laser emitter 126. Thus,each sensor module can have a capability of projecting laser beams,infrared light or visible light on a retina of an eye, the reflection ofwhich being captured by the high-resolution cameras 125. The sensormodules 121 and 122 can be installed in a head-mounted device or ingoggles. Other implementations are possible.

Although the eye examination apparatus 200 is depicted with the sensormodules 121 and 122, it is noted that other implementations are possiblein which there are no such modules. For instance, the eye examinationapparatus 200 can be provided with a first camera coupled to the bodyand positioned to acquire ophthalmic images through the first eyeopening 101, and a second camera coupled to the body and positioned toacquire ophthalmic images through the second eye opening 102. Suchcameras can be provided without the infrared projectors/sensors 123 andwithout the laser emitter 126. The cameras 125 can be installed in ahead-mounted device or in goggles. Other implementations are possible.

In some implementations, as shown in the illustrated example, (i) afirst camera (e.g. camera 125 of the sensor module 121) is positioned toacquire ophthalmic images through the first eye opening 101 via line ofsight through the semi-transparent mirror 106, and the first display 119is viewable through the first eye opening 101 via reflection off of thesemi-transparent mirror 106, and (ii) a second camera (e.g. camera 125of the sensor module 122) is positioned to acquire ophthalmic imagesthrough the second eye opening 102 via line of sight through thesemi-transparent mirror 106, and the second display 120 is viewablethrough the second eye opening 102 via reflection off of thesemi-transparent mirror 106.

In other implementations, (i) the first camera (e.g. camera 125 of thesensor module 121) is positioned to acquire ophthalmic images throughthe first eye opening 101 via reflection off of the semi-transparentmirror 106, and the first display 119 is viewable through the first eyeopening 101 via line of sight through the semi-transparent mirror 106,and (ii) the second camera (e.g. camera 125 of the sensor module 122) ispositioned to acquire ophthalmic images through the second eye opening102 via reflection off of the semi-transparent mirror 106, and thesecond display 120 is viewable through the second eye opening 102 vialine of sight through the semi-transparent mirror 120.

Although the illustrated example depicts a semi-transparent mirror 106for reflection, it is noted that a semi-transparent prism can beutilized instead. It is noted that a semi-transparent prism could causemore refraction than a semi-transparent mirror, depending on geometry ofcourse. It is implementation-specific whether a semi-transparent mirroror prism is utilized. In either case, light is enabled to pass throughthe semi-transparent mirror or prism, generally with line or sight,albeit with some amount of refraction. In specific implementations, asshown in the illustrated examples, the semi-transparent mirror 106 isoriented at 45-degree angle relative to the sensor modules 121 and 122and the at least one display 119 and 120 to facilitate reflections,given that the sensor modules 121 and 122 and the at least one display119 and 120 are orthogonal to one another. However, other geometries arepossible and are within the scope of the disclosure.

In some implementations, the eye examination apparatus 200 is equippedwith at least one condenser lens 154 for funduscopy, as similarlydescribed above with reference to FIG. 1 i.

In some implementations, the eye examination apparatus 200 is equippedwith components for interferometry such as a low coherence light source153 a and a mirror 156 for OCT, as similarly described above withreference to FIG. 1 j . In some implementations, the eye examinationapparatus 200 also has a lens 151 and a 2D MEMS mirror 155, as similarlydescribed above with reference to FIG. 1 i.

In some implementations, the eye examination apparatus 200 is equippedwith a refraction apparatus 188 for refraction eye examination, assimilarly described above with reference to FIGS. 1 k to 1 n.

In some implementations, the eye examination apparatus 200 is equippedwith at least one occlude, for example a pair of occludes, as similarlydescribed above with reference to FIG. 1 o.

In some implementations, the first eye opening 101 and the second eyeopening 102 of the eye examination apparatus 200 are separate openingsas depicted. However, other implementations are possible in which thethe first eye opening 101 and the second eye opening 102 are part of thesame opening, namely a large opening that enables the user to see intothe eye examination apparatus 100 using both eyes. In someimplementations, the eye examination apparatus 200 has a middle wall 109separating a left side for examining the user's left eye from a rightside for examining the user's right eye.

Referring now to FIGS. 2 c to 2 f , shown are perspective views of theeye examination apparatus 200 implemented with a headband 130 and 131.In some implementations, the headband 130 and 131 includes an upperheadband 130 and a lower headband 131 to enable the eye examinationapparatus 200 to be worn as goggles. In some implementations, the eyeexamination apparatus 200 has a nose rest 175 for precise positioning ofthe goggles. In some implementations, the eye examination apparatus 200is designed in a form of head-mounted goggles to be used in professionalestablishments and clinics such as nursing stations, emergency rooms,and ophthalmology, neurology or optometry offices. Other implementationsare possible.

In some implementations, the eye examination apparatus 200 has aprocessing unit for controlling the first sensor module, the secondsensor module, and the at least one display. In some implementations,the processing unit is configured to process ophthalmic images capturedby the high resolution cameras 125 and transmit them to a clinician forfurther analysis and examination. In some implementations, theprocessing unit is disposed within a processor unit housing 129 on anupper portion of the eye examination apparatus 200, Otherimplementations are possible. In some implementations, the processingunit is an MCU (Microcontroller Unit), although other processors such asCPU (Central Processing Unit), FPGA (Field Programable Gate Array), andASIC (Application Specific Integrated Circuit) are possible.

In some implementations, the eye examination apparatus 200 hasadjustable lenses 132 for the first eye opening 101 and the second eyeopening 102. The adjustable lenses 132 can enable the user to see thedisplay screens 119 and 120 either via line of sight or via a 90-degreereflection off of the semi-transparent mirror 106, depending on how theeye examination apparatus 200 is implemented. The adjustable lenses 132also facilitate capturing images of the eyes of the user using thehigh-resolution camera/scanner 125. Other implementations are possible.

In some implementations, the eye examination apparatus 200 has at leastone external sensor 128 configured to sense an environment external tothe eye examination apparatus 200, and the processing unit controls theat least one display based on the at least one external sensor 128. Insome implementations, the at least one external sensor 128 includes apair of external cameras 128 configured to capture the environmentexternal to the eye examination apparatus 200, and the processing unitgenerates images for the at least one display using the pair of externalcameras 128, This can enable augmented reality.

The eye examination apparatus 200 shown in FIGS. 2 c to 2 f isimplemented with the headband 130 and 131 for securing the eyeexamination apparatus 200 to the user. In another implementation, theeye examination apparatus 200 is implemented with a helmet to be worn bythe user. An example of this will be described below. Note that othersecuring means are possible and are within the scope of the disclosure.

Referring now to FIGS. 2 g to 2 l , shown are perspective views of theeye examination apparatus 200 implemented with a helmet 134. In someimplementations, the helmet 134 includes earphones 133 as well. In someimplementations, the eye examination apparatus 200 has a nose rest 175for precise positioning of the helmet. In some implementations, the eyeexamination apparatus 200 is designed in a form of head-mounted helmetto be used in professional establishments and clinics such as nursingstations, emergency rooms, and ophthalmology, neurology or optometryoffices. Other implementations are possible.

Referring now to FIGS. 3 a to 3 c , shown are perspective views ofanother eye examination apparatus 300 that can be used in a professionalsetting. Unlike the eye examination apparatus 200 described withreference to FIGS. 2 a to 2 l , the eye examination apparatus 300 ofFIGS. 3 a to 3 c does not have eye openings for a user to see inside aregion having displays/cameras, but rather is equipped with a visorhaving a transparent display 136 and camera assemblies 141. Still, theeye examination apparatus 300 of FIGS. 3 a to 3 c operates using similarprinciples as described above for the eye examination apparatus 200 ofFIGS. 2 a to 2 l.

In some implementations, the eye examination apparatus 300 isimplemented with a helmet 135. In some implementations, the helmet 135includes earphones 133 as well. In some implementations, the eyeexamination apparatus 300 is designed in a form of head-mounted helmetto be used in professional establishments and research labs and can beused by pilots, elite athletes, etc. Other implementations are possible.

Each camera assembly 141 includes a camera. In some implementations,each camera assembly 141 includes a mirror or prism positioned to enablethe camera to acquire ophthalmic images via reflection off of the mirroror prism. In some implementations, the camera assemblies 141 areretractable. In the illustrated example, the camera assemblies 141 in adeployed position, which enables the camera assemblies 141 to acquireophthalmic images. However, when not in use, the camera assemblies 141can be retracted into the eye examination apparatus 300.

In some implementations, images displayed on the transparent display 136are overlaid on a view of an environment that can be seen through thevisor, thereby enabling augmented reality. In some implementations, thevisor and the transparent display 136 are also retractable. In theillustrated example, the transparent display 136 in a deployed position,which enables the camera assemblies 141 to acquire ophthalmic images.However, when not in use, the camera assemblies 141 can be retractedinto the eye examination apparatus 300.

In some implementations, the eye examination apparatus 300 has aprocessing unit for the transparent display 136 and the cameraassemblies 141. In some implementations, the processing unit isconfigured to process ophthalmic images captured by the cameraassemblies 141 and transmit them to a clinician for further analysis andexamination. In some implementations, the processing unit is disposedwithin a processor unit housing 137 on an upper portion of the eyeexamination apparatus 300. Other implementations are possible. In someimplementations, the processing unit is an MCU, although otherprocessors such as CPU, FPGA, and ASIC are possible.

In some implementations, the eye examination apparatus 300 has motionand/or position sensors, and the processing unit controls thetransparent display 136 based on the motion and/or position sensors.

In some implementations, the eye examination apparatus 300 is equippedwith a refraction apparatus 188 for refraction eye examination, assimilarly described above with reference to FIGS. 1 k to 1 n.

In some implementations, the eye examination apparatus 300 is equippedwith at least one occlude, for example a pair of occludes, as similarlydescribed above with reference to FIG. 1 o.

Example Applications

The eye examination apparatuses 100, 200 and 300 described herein havevarious applications as explained below. While many of theseapplications are described below in relation to the “smartphoneembodiment” (i.e. the eye examination apparatus 100 depicted anddescribed with reference to FIGS. 1 a to 1 p ), it is to be understoodthat they can similarly be used in relation with the “professionalembodiments” (i.e. the eye examination apparatus 200 depicted anddescribed with reference to FIGS. 2 a to 2 l and/or the eye examinationapparatus 300 depicted and described with reference to FIGS. 3 a to 3 c). Other applications maybe possible.

Visual Acuity: A specifically designed mobile application can enable theeye examination apparatus and the primary and secondary DCSs toprecisely define the visual acuity of the users using one of thewell-established, reliable and currently used eye testing systems i.e.HOTV. The application can provide instructions to the patient via verbaland/or written instructions and upon confirmation provided by the user,it can prompt the user to put a primary and optionally a secondary DCS(smartphone) into their respective cartridge slots of the eyeexamination apparatus 100. A default test begins by testing the righteye unless the right eye is non-functional or chosen otherwise by theuser or the examiner (optometrist/physician). Random selection of H, O,T or V letters with sizes equivalent to 20/50 on Snellen's chart letterscan be shown at a center of the display with a predetermined sizereference letters at four sides. The user can then be prompted torespond if they recognize the letters and provide feedback in form of aneye or head movement toward the correct reference letter, vocal responseor touchscreen input. Upon correct answers for three consecutivepresentations, the size of the letters can be reduced, and the test canrepeat itself. Alternatively, the size of the letters can increase aftertwo consecutive wrong answers in the first set of presentations. As theuser recognizes the letters and correctly spots them on the screen, thesize of the target letters can be reduced. This process can continueuntil the user fails to provide three correct answers. A last lettersize that the user is able to recognize reliably can be considered astheir visual acuity. The cameras of the primary and secondary DCSs trackthe eyes during the visual acuity testing to ensure that the user gazedat the target.

Visual Field: The application, the eye examination apparatus, along withthe primary and secondary DCSs, are also useful for performing automatedvisual field testing i.e. automated perimetry analysis. The patients orthe examiners can determine a density and a span of a peripheral visualfield to test. They can either choose to test a narrow span of thevisual field (i.e. around the center of the vision) with high densitytest targets or a larger span of visual field with a variable density oftest targets. Using a statistical model, brightness and locations oftarget lights can be randomly determined and the test gradually becomesharder/complex until a defined brightness/contrast threshold is reachedat any tested peripheral target points. This analysis allows diagnosisof various neurological diseases based on the unique patterns of visualloss, for example, the inferior nasal visual field loss in glaucoma.Capturing and studying the pattern of visual loss can help theartificial intelligence and the examiner/physician to improve speed andprecision of diagnosis. Results obtained can be conveniently stored in asecure system for further analysis and follow-up.

Color Vision: The eye examination apparatus can be employed to perform astandard color deficiency test. Numbers with different colors are shownto the patient and patient's feedback is collected and analyzed todetect different types of color blindness.

Amsler Grid: Amsler grid test is a screening test used to detect signsof diseases that damage retina or the optic nerve. Some examples ofthese conditions include Age Related Macular Degeneration, retinaldetachment and optic neuritis all of which can lead to permanentblindness if not treated. Early detection and intervention are crucialin successful treatment of these conditions which emphasize theimportance of screening tests in detection and management of thesepotentially disabling conditions. A grid of black lines spanning 20-30degrees of the central field of vision is shown to each eye and thepatient is asked to report any imperfection or distortion in the gridlines. Presence of imperfections prompts the physician to perform morethorough examinations leading to early diagnosis and treatment of theabove-mentioned conditions.

Eye tracking: The cameras of the primary and secondary DCSs and theapplication are equipped with eye-tracking features. This is especiallyuseful for detection and analysis of conditions that affect eye movementsuch as concussion, multiple sclerosis, traumatic brain injury, andneurodegenerative brain diseases (for example, Alzheimer's disease,Parkinson's disease, Fronto-Temporal Dementia. Using the eye-trackingfeature, the eye examination apparatus can examine patients' eyemovements while performing tasks such as self-paced saccades or smoothpursuit to further analyze the course of the disease and assess theeffectiveness of the treatments.

With advancement in smartphone and mobile technology, display resolutionand camera resolution continue to improve which can improve visualacuity testing and other eye measurements by the eye examinationapparatus.

Various other applications of the eye examination apparatus includeobservation and analysis of:

-   -   afferent and efferent visual functions;    -   static eye features: eyelids, eyelid fissures, irises, pupil        shape and size, pupil color and sclera.    -   dynamic eye features: blinking, opening and closure of the eyes,        pupil changes to light and near/far vision, regularity of the        pupil reactions, and various eye movements,    -   testing the dry eye syndrome (or equivalent eye abnormalities        e.g. computer-eye syndrome etc.)    -   testing the refraction of the eyes to define the prescription of        glasses;    -   optic nerve, retina and their vascular features; and    -   refraction measurement for other purposes.

Further, the eye examination apparatus can be employed to perform avariety of routine eye examinations to diagnose and assess common tosevere eye conditions, a few of which are explained briefly hereunder.

Afferent Visual System (AVS)

AVS is related to all visual and brain functions that are responsiblefor capturing the images from the environment and analyzing them inorder to create visual perceptions. AVS is measured through differentvisual attributes including visual acuity, visual field, color vision,stereovision, depth perception, pupil size/shape in reaction to lightand/or distance, and the integrity of peripheral vision such as Amslergrid test.

Visual acuity: Visual acuity test is a measure of visual clarity at thecenter of vision (occasionally visual acuity is measured at peripheralvision as well). The clarity of vision is compared to the average visualclarity in the normal population which is called visual acuity.Different methods at different distances are used to test visual acuity,such as E-Chart, stylized letters, Landolt rings, pediatric symbols, orsymbols for the illiterate. The standard measure of reporting normalvisual acuity are 6/6 or 20/20, in Europe and North America,respectively. 20/20 or 6/6 vision means that the observer can clearlysee a target at 20 feet (or 6 meters) (representing the nominator) ascan a person with average normal vision (represented by denominator).However, if someone has reduced vision, for example 6/12 or 20/40, itmeans that the person can see a target clearly at 6 meters (20 feet)whereas an individual with average normal vision can see the same sizeobject at 12 meters (40 feet).

Traditionally with E-chart visual acuity testing the size of the letterthat needs to be seen clearly to represent 20/20 vision was determinedto be 5 arc minutes (1 arc minute is 1/60 of a degree of visual angle).The letter E has 3 sequences of dark and bright lines that need to bedistinguished before the observer can clearly recognize the letter andits direction. More recently, the HOTV method of visual acuity testinghas become a standard test. The HOTV system contains the letters (H, O,T, and V) which involves distinction of 3 repetition of light and brightpixels before the letter is distinguished. Therefore, vision withclarity of recognizing an image at 1.6 arc minute (the lettersrepresenting 20/20 vision) can recognize HOVT letters. As such themajority of commercially available cellphones since 2012 (over 70cellphone models-see cellphone table) can provide close or above 37.5PPD (pixel per degree) (representing 1.6 arc minute at Eye examinationapparatus resolution and can be used to test 20/20 vision with HOTVsystem.

Visual field and peripheral vision: Peripheral vision is a fundamentalpart of vision that provides awareness of the environment that canprevent accidents, collisions with objects approaching from the cornersof the vision, etc.

Measuring the visual field can be performed during an eye examination bya physician i.e. confrontation visual field test, which is neithersensitive nor specific. Alternatively, visual field testing can be doneautomatically by a physician or optometrist most commonly at a doctoroffice where the individual sits in front the machine and fixates at thecenter of the visual field; depending on the model of the visual fieldtest machine the visual stimuli either is moved or flashed manually orby the machine at different areas of the visual field; visualstimulation is usually a dot of light. The patient responds to seeingthe light by notifying the examiner or clicking a button. Sophisticatedautomatic visual tests use statistical models to increase thereliability as well as reduce the duration of the tests. These tests cannow be performed virtually using the eye examination apparatus.

Color vision: Color vision is defined as the ability of visual system todiscriminate between different wavelengths of light within visible lightspectrum regardless of its intensity¹. Humans are able to see colors dueto the presence of cone retinal photoreceptors. Their peak sensitivityvaries in three ranges of short (˜535 nm) medium (˜565 nm) and long(˜440 nm) wavelengths. Hence, they are called S, M and Lphotoreceptors². Color blindness is a condition in which colors are notperceived properly. It can happen due to loss of cones (dichromacy),changes in spectral sensitivity of cones (anomalous trichromacy) ordamage to the optic nerve or visual cortex. These could happengenetically or due to diseases or toxin-induced insults to the retinal,optic nerve or cortical cells³. ¹DeValois K, Webster M. Color vision.Scholarpedia. 2011: 6(4):3073.² DeValois K, Webster M. Color vision.Scholarpedia, 2011; 6(4):3073.³ DeValois K, Webster M. Color vision.Scholarpedia. 2011; 6(4):3073.

Stereovision, depth perception and stereoscopic display: Stereoscopicdisplay, also called 3D display or head-mounted display (HMD) comprisesa visual display e.g. LCD or LED display, in front of each eye thatworks based on the principle of stereopsis⁴. It operates by showingslightly different 2D perspectives of the same object to each eye. Theminor deviation of the object between the images is precisely equal tothe natural perspective of the binocular vision. This deviation createsan illusion of a 3D environment⁵ and helps vision in its depthperception. ⁴ Woods A J. Crosstalk in stereoscopic displays: a review. JElectron Imaging. 2012 Dec. 5; 21(4):040902.⁵ Woods A J. Crosstalk instereoscopic displays: a review. J Electron Imaging. 2012 Dec. 5;21(4):040902.

Pupillary response: Pupils respond to near/far objects and light bycontraction and relaxation. These are called near/light pupil response.In the near response, pupils contract because the human lens naturallydistorts light near its periphery. Pupils naturally constrict in nearobject vision to avoid this distortion and enhance visual clarity⁶.Pupils constrict in response to bright light to reduce the amount oflight entering the eye. ⁶ Pupillary reflex—Wikipedia. McGraw-Hill; 2012

Efferent Visual System (EVS)

Efferent visual system (EVS) functions relate to all visual and brainfunctions that are related to eye movements, reflexes and alignment. EVSassessment includes measuring eye alignment/misalignment,saccadic/pursuit eye movements and the eye movement components. Thesecomponents include saccade amplitude, accuracy, maximum speed, andnumber of saccades in self-paced, memory-based and reflexive (i.e.visually targeted) saccades. Moreover, EVS measurements include abnormaleye movements such as nystagmus/oscillation/intrusions of the eye atneutral or different gaze positions, and eye reflexes such asvestibulo-ocular-reflex (VOR) and inhibition (VOI).

Pursuit eye movement: Smooth pursuit eye movements are slower thansaccades and evolved to fixate on a moving object at the center ofvision i.e. when the image is fallen on the fovea⁷. This movement isunder voluntary control. However, in the absence of an object onlyhighly trained individuals are able to make smooth pursuits eyemovements and most of the people will simply perform saccades⁸. Smoothpursuit is highly controlled by the brain (frontal eye field in thefrontal lobe). ⁷ Purves D, Augustine G J, Fitzpatrick D, Katz L C,LaMantia A-S, McNamara J O, et al. Types of Eye Movements and TheirFunctions, 2001.⁸ Purves D, Augustine G J, Fitzpatrick D, Katz L C,LaMantia A-S, McNamara J O, et al. Types of Eye Movements and TheirFunctions, 2001.

Saccade: A saccade is defined as a synchronous and rapid movement of theeyes between two points⁹. In comparison to VOR response that iscontrolled by a relatively straightforward pathways, saccadic responseis driven by complex and polysynaptic pathways that originate from thefrontal eye field (FEF) cerebellum, or superior colliculus¹⁰. ⁹Takahashi M, Shinoda Y. Brain Stem Neural Circuits of Horizontal andVertical Saccade Systems and their Frame of Reference. Neuroscience.2018 Nov. 10; 392:281-328.¹⁰ Termsarasab P, Thammongkoichai T. Rucker JC, Frucht S J. The diagnostic value of saccades in movement disorderpatients: a practical guide and review. J Clin Mov Disord. 2015 Oct. 15;2:14.

Self-paced Saccade: Self-paced saccade (SPSs) is defined as a voluntarysaccade between two fixed targets. The anterior cingulate cortex isresponsible for maintaining the motivation to perform the task. The FEF,prefrontal cortex (dorsolateral part) and superior colliculus of themidbrain constitute the pathways that govern self-pacedsaccades^(11,12). More precisely, to generate a horizontal saccadeinitiation, signals from the FEFs are sent to paramedian reticularformation in pons to activate cranial nerve 6 nucleus. Further, thesignal will continue to go to midbrain from Medial LongitudinalFasciculus (MLF) to activate cranial nerve 3 nucleus. These 2 cranialnuclei are fundamentally responsible for horizontal eye movements. Thevertical saccade is generated by initiation signals from FEFstransmitted to the rostral interstitial nuclei of MLF, 3ed and 4thcranial nerves^(13,14) which in turn generate and control vertical eyemovements. ¹¹ Heitger M H, Anderson T J, Jones R D, Dalrymple-Alford JC, Frampton C M, Ardagh M W. Eye movement and visuomotor arm movementdeficits following mild closed head injury. Brain. 2004 March; 127(Pt3):575-90.¹² Heitger M H, Jones R D, Macleod A D, Snell D L, Frampton CM, Anderson T J. Impaired eye movements in post-concussion syndromeindicate suboptimal brain function beyond the influence of depression,malingering or intellectual ability. Brain. 2009 October; 132(Pt10):2850-70.¹³ Williams I M, Ponsford J L, Gibson K L, Mulhall L E,Curran C A, Abel L A. Cerebral control of saccades andneuropsychological test results after head injury. J Clin Neurosci. 1997April; 4(2):186-96.¹⁴ Heitger M H, Anderson T J, Jones R D,Dalrymple-Alford J C, Frampton C M, Ardagh M W. Eye movement andvisuomotor arm movement deficits following mild closed head injury.Brain. 2004 March; 127(Pt 3):575-90.

Studies on mTBI patients have revealed impairments of severalcharacteristics of horizontal SPSs such as total number of saccades andintersaccadic intervalsis¹⁵. Patients with mTBI performed fewer SPSswith a significantly increased intersaccadic interval which indicatesimpairment of the prefrontal function^(16,17). In addition to theparameters mentioned above, other parameters such as saccadic velocityto accuracy ratio (S/A ratio) and saccade gain are among common metricsto evaluate horizontal saccadic performance^(18,19). Studies have alsodemonstrated impairment in vertical saccadic performance such asefficiency, amplitude, peak, acceleration and position errors followingmTBI²⁰. ¹⁵ Taghdiri F, Chung J, Irwin S. Multani N, Tarazi A, EbraheemA, et al. Decreased Number of Self-Paced Saccades in Post-ConcussionSyndrome Associated with Higher Symptom Burden and Reduced White MatterIntegrity. J Neurotrauma, 2018 Mar. 1; 35(5):719-29.¹⁶ Taghdiri F, ChungJ, Irwin S, Multani N, Tarazi A, Ebraheem A, et al. Decreased Number ofSelf-Paced Saccades in Post-Concussion Syndrome Associated with HigherSymptom Burden and Reduced White Matter Integrity. J Neurotrauma. 2019Mar. 1; 35(5):719-29.¹⁷ Heitger M H, Jones R D, Macleod A D, Snell D L,Frampton C M, Anderson T J. Impaired eye movements in post-concussionsyndrome indicate suboptimal brain function beyond the influence ofdepression, malingering or intellectual ability. Brain. 2009 October;132(Pt 10):2850-70.¹⁸ Hunfalvay M, Roberts C-M, Murray N, Tyagi A, KellyH, Bolte T. Horizontal and vertical self-paced saccades as a diagnosticmarker of traumatic brain injury. Concussion. 2019 Jul. 25;4(1):CNC60.¹⁹ Cifu D X, Wares J R, Hoke K W, Wetzel P A, Gitchel G, CameW. Differential eye movements in mild traumatic brain injury versusnormal controls. J Head Trauma Rehabil. 2015 February; 30(1):21-8.²⁰Hunfalvay M, Roberts C-M, Murray N, Tyagi A, Kelly H, Bolts: T,Horizontal and vertical self-paced saccades as a diagnostic marker oftraumatic brain injury. Concussion. 2019 Jul. 25; 4(1):CNC60.

Reflexive (visual targets) saccades: Reflexive saccades are defined inrelation to voluntary saccades. While the latter involve voluntarilycontrolled cognitive processes, reflexive saccades occur in response tothe appearance of a new target eccentric to the point of fixation²¹. ²¹Walker J. Human saccadic eye movements. Scholarpedia. 2012; 7(7):5095.

Memory based saccade: Memory-guided saccade is defined as a saccade tothe place of a target that flashed briefly. This involves rememberingthe location of the briefly visible target. A defect in the basalganglia or frontal lobes where working memory is processed, results inmemory guided saccade dysfunction²². ²² Walker J. Human saccadic eyemovements. Scholarpedia. 2012; 7(7):5095.

Saccade velocity: Most frequently measured velocity parameter is peaksaccade velocity. It is defined as the maximum speed of the eyes duringa saccade. The typical peak velocity of saccades in a normal personranges from 30 to 700 degrees/s with an amplitude between 0.5 to 40degrees²³. Changes in peak saccade velocity could be a viable indicatorof psychophysiological arousal (sympathetic nervous system activation),mental activity workload or prediction of the subsequent fixation pointvalue^(24,25,26). ²³ Wong A M F. Eye Movements; Saccades. Encyclopediaof the neurological sciences. Elsevier; 2014. p. 249-51.²⁴ Di Stasi L L,Catena A, Camas J J, Macknik S L, Martinez-Conde S. Saccadic velocity asan arousal index in naturalistic tasks. Neurosci Biobehav Rev. 2013June; 37(5):968-75.²⁵ Brunyé T T, Drew T, Weaver D L, Elmore J G. Areview of eye tracking for understanding and improving diagnosticinterpretation. Cogn Research. 2019 Feb. 22; 4(1):7.²⁶ Xu-Wilson M, ZeeD S, Shadmehr R. The intrinsic value of visual information affectssaccade velocities. Exp Brain Res. 2009 July; 196(4):475-81.

Time to peak velocity: As previously described, saccadic peak velocityis defined as the maximum velocity reached during a saccade. The timespent between the beginning of the saccade until reaching the peak ofvelocity is called time to peak velocity.

Saccade accuracy, latency and amplitude: Saccade accuracy is theaccuracy with which a saccade fixates a target on the center of fovea.Average landing error and average landing variability are two parametersthat are used to measure accuracy and precision of the saccadesrespectively²⁷. Studies have shown that even small saccades (between 14to 20 degrees) are accurate enough to precisely center the stimulus onthe fovea²⁸. Studies have demonstrated alterations in saccadic accuracyfollowing mild traumatic brain injury²⁹. This indicates the potential ofthese parameters for the diagnosis and follow up of the patientsuffering from mTBI. ²⁷ Poletti M, Intoy J, Rucci M. Accuracy andprecision of small saccades. Sci Rep. 2020 Sep. 30; 10(1):16097²⁸Poletti M, Intoy J, Rucci M. Accuracy and precision of small saccades.Sci Rep. 2020 Sep. 30; 10(1):16097.²⁹ Heitger M H, Jones R D, Macleod AD, Snell D L, Frampton C M, Anderson T J. Impaired eye movements inpost-concussion syndrome indicate suboptimal brain function beyond theinfluence of depression, malingering or intellectual ability. Brain.2009 October; 132(Pt 10):2350-70.

Saccade gain: Saccade gain is calculated based on the saccade amplitudeand is a parameter that is used to measure saccade accuracy. Thisparameter defines if the saccade is hypo- or hypermetric and calculatedby dividing the actual saccade amplitude by desired saccade amplitude³⁰.³⁰ Knox Paul, “The parameters of eye movement”, accessed 2020 December,www.docenti.unina.it/webdocentibe/allegati/materiale-didattico/412703

Position error: Is a parameter to measure the motor accuracy ofsaccades. It is closely related to saccade gain. The mean absoluteposition error measures the difference between desired and actual eyeposition. However, saccade amplitude clarifies the direction of thaterror by showing weather there was a hypo- or hypermetria. Theseparameters are effective means of measuring the impact of TBI onsaccadic eye movements³¹. “Mean absolute position error of the final eyeposition [PEreflexive=|(EPfin−SP)/SP|×100], gain of the primary saccade(Gp=EPprim/SP) and gain of the final eye position (Gf=EPfin/SP), whereEPprim is the eye position after the initial saccade, EPfin is the finaleye position and SP is the stimulus position”³². ³¹ Heitger M H,Anderson T J, Jones R D, Dalrymple-Alford J C, Frampton C M, Ardagh M W.Eye movement and visuomotor arm movement deficits following mild closedhead injury. Brain. 2004 March; 127(Pt 3):575-90.³² Heitger M H,Anderson T J, Jones R D, Dalrymple-Alford J C, Frampton C M, Ardagh M W.Eye movement and visuomotor arm movement deficits following mild closedhead injury. Brain. 2004 March; 127(Pt 3):575-90.

Saccadic intrusions: Saccadic intrusions are defined as saccades thatinterrupt fixation. They happen irregularly and categorized based onwhether or not they are separated by a brief interval of fixation. Someexamples of the saccades that possess an intersaccadic interval includesquare wave jerks, macro-saccadic oscillations and macro square wavejerks. Among those that happen as back-to-back saccades without anyintersaccadic interval, are opsoclonus, voluntary nystagmus and ocularflutter³³. While saccadic intrusions could be found in normalindividuals, they could also indicate underlying disorders/dysfunctionof brainstem, cerebellum, superior colliculus, basal ganglia orcerebellum. ³³ Lernos J, Eggenberger E. Saccadic intrusions: review andupdate. Curr Opin Neurol. 2013 February; 26(1):59-66.

Vestibulo-ocular reflex and inhibition: Vestibulo-ocular reflex (VOR) isa 3-dimensional reflex governed by the inner ear vestibular system andinvolves cranial nerves III, IV, VI, VIII, their respective nuclei, aswell as medial longitudinal fasciculus (MLF) to maintain visualstability during head movement. VOR stabilizes gaze by moving the eye tothe opposite direction from the head movement. A defect in thevestibular system, the associated nuclei or their interconnectingpathways could lead to a dysfunctional VOR³⁴. Conversely, theVestibulo-ocular inhibition (VOI) demonstrates the ability of the EVS toinhibit VOR when the head follows a moving object by rotating the wholebody and keeping the eye stationary and fixated on the target. ³⁴Halmagyi G M, Chen L, MacDougall H G, Weber K P, McGarvie L A, CurthoysI S. The video head impulse test. Front Neural. 2017 Jun. 9; 8:258.

Dynamic visual acuity: Maintaining visual acuity during head movement(dynamic visual acuity) is the outcome of an interplay betweenvestibular, visuomotor and visual systems³⁵. Normally, there is acertain degree of reduction in visual acuity during movement. Reductionof visual acuity during movement beyond its normal range (oscillopsia)indicates a non-compensated insult to the pathways responsible forVOR³⁶. Recent studies have established a relationship between recoveryof dynamic visual acuity parameters and improvement of post-concussionsyndrome³⁷. ³⁵ Landers M R, Donatelli R, Nash J, Bascharon R. Evidenceof dynamic visual acuity impairment in asymptomatic mixed martial artsfighters. Concussion. 2017 November; 2(3):CNC41.³⁶ Landers M R,Donateili R, Nash J, Bascharon R. Evidence of dynamic visual acuityimpairment in asymptomatic mixed martial arts fighters. Concussion. 2017November; 2(3):CNC41.³⁷ Landers M R, DonateIli R, Nash J, Sascharon R.Evidence of dynamic visual acuity impairment in asymptomatic mixedmartial arts fighters. Concussion. 2017 November; 2(3):CNC41.

Nystagmus: Nystagmus is defined as involuntary eye movement in ahorizontal, vertical or rotatory fashion. Based on movement speed, twotypes of nystagmus could be distinguished from each other³⁸. Pendularnystagmus is a type that consists of slow sinusoidal oscillations inboth phases while Jerk nystagmus is characterized by a slow drift and arapid corrective saccades³⁹. ³⁸ Leigh R J, Zee D S. The neurology of eyemovements. Oxford University Press; 2015.³⁹ Leigh R J, Zee D S. Theneurology of eye movements. Oxford University Press; 2015.

Proper characterization of nystagmus helps with the diagnosis ofcausative defects and pathologies. The first step in finding the causeof the nystagmus is to determine the effect of removing the fixation onthe severity of the nystagmus. As an example, increasing the severity ofnystagmus after removing fixation indicates a peripheral origin⁴⁰. Aperipheral nystagmus that is caused by a peripheral vestibular pathologyusually causes a jerk nystagmus that beats away from the side of thelesion. In contrast, a congenital nystagmus is usually horizontal andaccentuated by fixation as well as anxiety⁴¹. Moreover, presence of apurely torsional or vertical jerk nystagmus while the eyes are at a nearcenter position mainly indicates a central lesion involving thevestibular pathways⁴². ⁴⁰ Serra A, Leigh R J. Diagnostic value ofnystagmus: spontaneous and induced ocular oscillations. J NeurolNeurosurg Psychiatr. 2002 December; 73(6):615-8.⁴¹ Serra A, Leigh R J.Diagnostic value of nystagmus: spontaneous and induced ocularoscillations. J Neurol Neurosurg Psychiatr. 2002 December;73(6):615-8.⁴² Serra A, Leigh R J. Diagnostic value of nystagmus:spontaneous and induced ocular oscillations. J Neurol NeurosurgPsychiatr. 2002 December; 73(6):615-8.

Structure of the Visual System

The measurements include (1) optic nerve thickness and shape, (b)retina/macula layers, thickness and shape and (3) vascular structure andlive function and reaction of the vessels to different maneuvers forexample Valsalva or fast breathing or visual stimulation such asstationary vs motion pictures. Ocular coherence tomography technologywill be placed at the display and cameras which can demonstratemicrostructure of the optic nerve, renita and their vessels.

Virtual Reality (VR)

A platform through which a computer generated 3D rendered environment ispresented to the viewer using one or more stereoscopic displays combinedwith a plethora of novel technologies such as head and eye trackingsensors, software frameworks, development tools and input devicespackaged in a head-mounted setup designed to create an illusion ofreality. Input devices enable the user to interact with the virtualenvironment⁴³. ⁴³ Cipresso F, Giglioli I A C, Raya M A, Riva G. Thepast, present, and future of virtual and augmented reality research: Anetwork and cluster analysis of the literature, Front Psychol, 2018 Nov.6; 9:2086.

Eye Tracking

Eye tracking is an objective method of assessing ocular function. Eyetracking systems and softwares are designed to measure different aspectsof ocular motor function including movement, position, latencies,frequency of moves, etc.⁴⁴. It also measures the pattern of eyemovements between the fixation points including saccade amplitude (indegrees), speed, number of saccades⁴⁵⁻⁴⁶, etc. Position measurescalculate the Cartesian coordinates of the gaze and latency measuresquantify the duration of saccades and fixations (defined as pause at aspatial location for more than 99 milliseconds). Moreover, the quantityof saccades and number for fixations and blinks are among mostly studiedfrequency measures⁴⁷. ⁴⁴ Holmqvist K, Nyström M, Andersson R, DewhurstR, Van de Weijer J. Eye Tracking: A Comprehensive Guide To Methods AndMeasures, 2011 Jan. 1.⁴⁵ Liversedge S P, Findlay J M. Saccadic eyemovements and cognition. Trends Cogn Sci (Regul Ed). 2000 January;4(1):6-14⁴⁶ Heitger M H, Jones R D, Macleod A D, Snell D L, Frampton CM, Anderson T J. Impaired eye movements in post-concussion syndromeindicate suboptimal brain function beyond the influence of depression,malingering or intellectual ability. Brain. 2009 October; 132(Pt10):2850-70⁴⁷ Brunyé T T, Drew T, Weaver D L, Elmore J G. A review ofeye tracking for understanding and improving diagnostic interpretation.Cogn Research, 2019 Feb. 22; 4(1):7

A typical eye tracking setup consists of an infrared or semi-infraredlight source, a camera and a software that processes the images andtracks the eye movement mainly through pupil tracking⁴⁸. Moresophisticated tracking systems include light emitters to produce lightreflections on the eye surface. The relative position of the reflectedpoints to the pupil will be used to calculate the eye position vectorsand point of regard⁴⁹. ⁴⁸ Brunyé T T, Drew T, Weaver D L, Elmore J G. Areview of eye tracking for understanding and improving diagnosticinterpretation. Cogn Research, 2019 Feb. 22; 4(1):7.⁴⁹Hansen D W, Ji Q.In the eye of the beholder: a survey of models for eyes and gaze. IEEETrans Pattern Anal Mach Intell. 2010 March; 32(3):478-500.

Diseases that the Eye Examination Apparatus can Help with Diagnosis andMonitoring Recovery

Another disease that the eye examination apparatus can help withdiagnosis and monitoring the recovery is Mild traumatic brain injury(mTBI). Proper eye movement relies extensively on the functionalintegrity of the brain and its pathways. Moreover, attention, responseinhibition, memory, motor planning and speed of information processingplay significant roles in the control of eye movements. Studies haveestablished a significant correlation between mTBI and impairment ofEVS⁵⁰. Interestingly, the eye movement deficits happen independent ofneuropsychological symptoms of mTBI⁵¹. Meta-analysis of studies focusedon neuropsychological sequelae of mTBI demonstrated that neurocognitivedeterminants of the post-concussion syndrome completely resolve 1-3months after the impact. Moreover, imaging entities have limited abilityin detecting abnormalities in patients with post-concussionsyndrome^(52,53). ⁵⁰ Heitger M H, Jones R D, Macleod A D, Snell D L,Frampton C M, Anderson T J. Impaired eye movements in post-concussionsyndrome indicate suboptimal brain function beyond the influence ofdepression, malingering or intellectual ability. Brain. 2009 October;132(Pt 10):2350-70.⁵¹ Heitger M H, Anderson T J, Jones R D,Dalrymple-Alford J C, Frampton C M, Ardagh M W. Eye movement andvisuomotor arm movement deficits following mild closed head injury.Brain. 2004 March; 127(Pt 3):575-90.⁵² Schretlen D J, Shapiro A M. Aquantitative review of the effects of traumatic brain injury oncognitive functioning. Int Rev Psychiatry. 2003 November; 15(4):341-9.⁵³Heitger M H, Jones R D, Macleod A D, Snell D L, Frampton C M, Anderson TJ. Impaired eye movements in post-concussion syndrome indicatesuboptimal brain function beyond the influence of depression,malingering or intellectual ability. Brain. 2009 October; 132(Pt10):2350-70.

The assessment of EVS and AVS abnormalities through the eye examinationapparatus can prove useful in identifying many eye and brain disorderssuch as: a. Eye diseases such as macular degeneration, glaucoma, opticneuropathy, etc. (AVS abnormalities); b. Neurodegenerative diseases likeParkinson disease, Alzheimer disease, etc.; c. Psychiatric diseases suchas schizophrenia, ADHD, etc. (AVS and EVS abnormalities); d. Common eyeconditions such as amblyopia.

Supported Smartphones

There are many possibilities for the smartphones that can be used withthe eye examination apparatus 100 described herein. The following is anon-excluding list of smartphones which may be used with the eyeexamination apparatus 100. It is to be understood that additionalsmartphones may be compatible as well.

Manufacturer and Year Screen model name introduced size Screen areaResolution Ratio PPI PPD Sony Xperia XZ 2017  5.46″ 12.74 square inches3840 × 2160 16:09 806.93 Premium (4.8″ × 2.7″) UHD-1 65.7 Sony Xperia Z52015 5.5″ 12.93 square inches 3840 × 2160 16:09 801.06 Premium (4.8″ ×2.7″) UHD-1 65.2 Samsung Galaxy 2015 5.1″ 11.11 square inches 2560 ×1440 16:09 575.92 S6 (4.4″ × 2.5″) QHD 46.4 Samsung Galaxy 2015 5.1″11.11 square inches 2560 × 1440 16:09 575.92 S6 Edge (4.4″ × 2.5″) QHD46.4 Samsung Galaxy 2016 5.1″ 11.11 square inches 2560 × 1440 16:09575.92 S7 (4.4″ × 2.5″) QHD 46.4 Samsung Galaxy 2017 5.8″ 13.23 squareinches 2960 × 1440 37:18:00 567.53 47 S8 (5.2″ × 2.5″) Samsung Galaxy2018 5.8″ 13.23 square inches 2960 × 1440 37:18:00 567.53 47 S9 (5.2″ ×2.5″) LG G6 2017 5.7″ 13 square inches 2880 × 1440  2:01 564.9 46.5(5.1″ × 2.5″) Microsoft Lumia 2015 5.2″ 11.55 square inches 2560 × 144016:09 564.85 950 (4.5″ × 2.5″) QHD 45.6 HTC 10 2016 5.2″ 11.55 squareinches 2560 × 1440 16:09 564.85 (4.5″ × 2.5″) QHD 45.6 Motorola Droid2014 5.2″ 11.55 square inches 2560 × 1440 16:09 564.85 Turbo (4.5″ ×2.5″) QHD 45.6 LG G7 ThinQ 2018 6.1″ 14.16 square inches 3120 × 144013:06 563.32 45.9 (5.5″ × 2.6″) LG G5 2016 5.3″ 12 square inches 2560 ×1440 16:09 554.19 (4.6″ × 2.6″) QHD 44.9 Samsung Galaxy 2019 6.1″ 14.4square inches 3040 × 1440 19:09 551.44 46.1 S10 (5.5″ × 2.6″) SamsungGalaxy 2014 5.6″ 14.09 square inches 2560 × 1600  8:05 539.08 Note Edge(4.7″ × 3″) WQXGA 43.9 Nokia 9 2019  5.99″ 14.35 square inches 2880 ×1440  2:01 537.55 44.7 (5.4″ × 2.7″) Huawei Mate 20 2018 6.4″ 15.58square inches 3120 × 1440 13:06 536.92 45.4 Pro (5.8″ × 2.7″) LG V40ThinQ 2018 6.4″ 15.58 square inches 3120 × 1440 13:06 536.92 45.4 (5.8″× 2.7″) LG V30 2017 6″   14.4 square inches 2880 × 1440  2:01 536.6644.6 (5.4″ × 2.7″) LG G3 2014 5.5″ 12.93 square inches 2560 × 1440 16:09534.04 (4.8″ × 2.7″) QHD 41.9 Oppo Find 7 2014 5.5″ 12.93 square inches2560 × 1440 16:09 534.04 (4.8″ × 2.7″) QHD 41.9 LG G4 2015 5.5″ 12.93square inches 2560 × 1440 16:09 534.04 (4.8″ × 2.7″) QHD 41.9 SamsungGalaxy 2016 5.5″ 12.93 square inches 2560 × 1440 16:09 534.04 S7 QHD41.9 Motorola Mobility 2016 5.5″ 12.93 square inches 2560 × 1440 16:09534.04 Moto Z (4.8″ × 2.7″) QHD 41.9 Google Pixel XL 2016 5.5″ 12.93square inches 2560 × 1440 16:09 534.04 (4.8″ × 2.7″) QHD 41.9 MotorolaMoto Z2 2017 5.5″ 12.93 square inches 2560 × 1440 16:09 534.04 Force(4.8″ × 2.7″) QHD 41.9 Samsung Galaxy 2019 6.3″ 15.36 square inches 3040× 1440 19:09 533.94 45 S10+ (5.7″ × 2.7″) Samsung Galaxy 2017 6.2″ 15.12square inches 2960 × 1440 37:18:00 530.92 44.5 S8+ (5.6″ × 2.7″) SamsungGalaxy 2018 6.2″ 15.12 square inches 2960 × 1440 37:18:00 530.92 44.5S9+ (5.6″ × 2.7″) Samsung Galaxy 2017 6.3″ 15.61 square inches 2960 ×1440 37:18:00 522.49 44 Note 8 (5.7″ × 2.8″) Google Pixel 3 2018 6.3″15.61 square inches 2960 × 1440 37:18:00 522.49 44 XL (5.7″ × 2.8″)Samsung Galaxy 2014 5.7″ 13.88 square inches 2560 × 1440 16:09 515.3Note 4 (5″ × 2.8″) QHD 42.3 Samsung Galaxy 2015 5.7″ 13.88 square inches2560 × 1440 16:09 515.3 Note 5 (5″ × 2.8″) QHD 42.3 Motorola Moto X 20155.7″ 13.88 square inches 2560 × 1440 16:09 515.3 Style (5″ × 2.8″) QHD42.3 Huawei Nexus 6P 2015 5.7″ 13.88 square inches 2560 × 1440 16:09515.3 (5″ × 2.8″) QHD 42.3 Samsung Galaxy 2016 5.7″ 13.88 square inches2560 × 1440 16:09 515.3 Note 7 (5″ × 2.8″) QHD 42.3 LG V20 2016 5.7″13.88 square inches 2560 × 1440 16:09 515.3 (5″ × 2.8″) QHD 42.3 SamsungGalaxy 2018 6.4″ 16.11 square inches 2960 × 1440 37:18:00 514.33 43.4Note 9 (5.8″ × 2.8″) Essential PH-1 2017  5.71″ 13.23 square inches 2560× 1312 80:41:00 503.79 41.5 (5.1″ × 2.6″) Samsung Galaxy 2019 6.7″ 17.37square inches 3040 × 1440 19:09 502.06 42.9 S10 5G (6.1″ × 2.9″) SamsungNote10+ 2019 6.8″ 17.89 square inches 3040 × 1440 19:09 494.68 42.4(6.1″ × 2.9″) Motorola Nexus 6 2014  5.96″ 15.18 square inches 2560 ×1440 16:09 492.82 (5.2″ × 2.9″) QHD 40.7 Sharp SH-02F 2014 4.5″ 8.65square inches 1920 × 1080 16:09 489.53 (3.9″ × 2.2″) FHD 38.8 Vivo Xplay3S 2014 6″   15.38 square inches 2560 × 1440 16:09 489.53 (5.2″ × 2.9″)QHD 40.5 Lenovo Vibe Z2 2014 6″   15.38 square inches 2560 × 1440 16:09489.53 Pro (5.2″ × 2.9″) QHD 40.5 HTC One 2013 4.7″ 9.44 square inches1080 × 1920  9:16 468.7 35.6 (2.3″ × 4.1″) Apple iPhone X 2017 5.8″ 12.8square inches 2436 × 1125 812:375 462.63 38.3 (5.3″ × 2.4″) Apple iPhoneXS 2018 5.8″ 12.8 square inches 2436 × 1125 812:375 462.63 38.3 (5.3″ ×2.4″) Apple iPhone 11 2019 5.8″ 12.8 square inches 2436 × 1125 812:375462.63 38.3 Pro (5.3″ × 2.4″) Sharp SH-06E 2013 4.8″ 9.84 square inches1920 × 1080 16:09 458.94 (4.2″ × 2.4″) FHD 36.6 Apple iPhone XS 20186.5″ 16.09 square inches 2688 × 1242 448:207 455.55 38.7 Max (5.9″ ×2.7″) Apple iPhone 11 2019 6.5″ 16.09 square inches 2688 × 1242 448:207455.55 38.7 Pro Max (5.9″ × 2.7″) BlackBerry 2014 4.5″ 10.13 squareinches 1440 × 1440  1:01 452.55 35.1 Passport (3.2″ × 3.2″) Google Nexus5 2013  4.95″ 10.47 square inches 1920 × 1080 16:09 445.03 (4.3″ × 2.4″)FHD 35.7 TCL Palm 2018 3.3″ 4.65 square inches 1280 × 720  16:09 445.03(2.9″ × 1.6″) WXGA-H 34.2 Google Pixel 3a 2019 5.6″ 12.34 square inches2220 × 1080 37:18:00 440.85 35.4 (5″ × 2.4″) HTC J Butterfly 2012 5″  10.68 square inches 1080 × 1920  9:16 440.58 35.4 (2.5″ × 4.4″) SamsungGalaxy 2013 5″   10.68 square inches 1920 × 1080 16:09 440.58 S4 (4.4″ ×2.5″) FHD 35.4 Sony Xperia Z 2013 5″   10.68 square inches 1080 × 1920 9:16 440.58 35.4 (2.5″ × 4.4″) Huawei Ascend D2 2013 5″   10.68 squareinches 1080 × 1920  9:16 440.58 35.4 (2.5″ × 4.4″) Nokia Lumia 929 20145.0″ 10.68 square inches 1920 × 1080 16:09 440.58 (4.4″ × 2.5″) FHD 35.4Nokia Lumia 930 2014 5″   10.68 square inches 1920 × 1080 16:09 440.58(4.4″ × 2.5″) FHD 35.4 Sony Xperia Z1 2013 5″   10.68 square inches 1920× 1080 16:09 440.58 (4.4″ × 2.5″) FHD 35.4 HTC Butterfly S 2013 5″  10.68 square inches 1920 × 1080 16:09 440.58 (4.4″ × 2.5″) FHD 35.4 HTCOne A9 2015 5″   10.68 square inches 1920 × 1080 16:09 440.58 (4.4″ ×2.5″) FHD 35.4 Google Pixel 2016 5″   10.68 square inches 1920 × 108016:09 440.58 (4.4″ × 2.5″) FHD 35.4 Google Pixel 2 2017 5″   10.68square inches 1920 × 1080 16:09 440.58 (4.4″ × 2.5″) FHD 35.4 GooglePixel 3 2018 5.5″ 12.1 square inches 2160 × 1080  2:01 439.08 35.9 (4.9″× 2.5″) LG Q6 Alpha 2017 5.5″ 12.1 square inches 2160 × 1080  2:01439.08 35.9 (4.9″ × 2.5″) Samsung Galaxy 2019 5.8″ 13.01 square inches2280 × 1080 19:09 434.98 36 S10e (5.2″ × 2.5″)

Numerous modifications and variations of the present disclosure arepossible in light of the above teachings. It is therefore to beunderstood that within the scope of the appended claims, the disclosuremay be practised otherwise than as specifically described herein.

We claim:
 1. An eye examination apparatus, comprising: a body having afirst eye opening and a second eye opening for a user to see into theeye examination apparatus using two eyes; a first camera coupled to thebody and positioned to acquire ophthalmic images through the first eyeopening; a second camera coupled to the body and positioned to acquireophthalmic images through the second eye opening; at least one displaycoupled to the body and positioned to be viewable through the first eyeopening and the second eye opening; and a semi-transparent mirror orprism coupled to the body; wherein: the at least one display ispositioned to either be viewable via line of sight through thesemi-transparent mirror or prism or by reflection off of thesemi-transparent mirror or prism; when the display is viewable via lineof sight through the semi-transparent mirror or prism, the first cameraand the second camera are positioned to acquire ophthalmic images viareflection off of the semi-transparent mirror or prism; and when thedisplay is viewable via reflection off of the semi-transparent mirror orprism, the first camera and the second camera are positioned to acquireophthalmic images via line of sight through the semi-transparent mirroror prism.
 2. The eye examination apparatus of claim 1, wherein: the atleast one display comprises a first display positioned to be viewablethrough the first eye opening and a second display positioned to beviewable through the second eye opening; the first camera is positionedto acquire ophthalmic images through the first eye opening viareflection off of the semi-transparent mirror or prism, and the firstdisplay is viewable through the first eye opening via line of sightthrough the semi-transparent mirror or prism; the second camera ispositioned to acquire ophthalmic images through the second eye openingvia reflection off of the semi-transparent mirror or prism, and thesecond display is viewable through the second eye opening via line ofsight through the semi-transparent mirror or prism.
 3. The eyeexamination apparatus of claim 2, further comprising: components forinterferometry including a first low coherence light source, a secondlow coherence light source, and at least one mirror; and wherein thefirst low coherence light source is positioned facing the at least onemirror through the semi-transparent mirror or prism, such that lowcoherence light from the first low coherence light source can be splitby the semi-transparent mirror or prism into a first reference lightwave through the semi-transparent mirror or prism and a first samplelight wave reflected off of the semi-transparent mirror or prism;wherein the first reference light reflects off of the mirror, reflectsoff of the semi-transparent mirror or prism, and is received by thefirst camera; wherein the first sample light wave light reflects off ofa first sample, passes through the semi-transparent mirror or prism, andis received by the first camera; and wherein the first camera ispositioned to detect interference between the first reference light waveand the first sample light wave; and wherein the second low coherencelight source is positioned facing the at least one mirror through thesemi-transparent mirror or prism, such that low coherence light from thesecond low coherence light source can be split by the semi-transparentmirror or prism into a second reference light wave through thesemi-transparent mirror or prism and a second sample light wavereflected off of the semi-transparent mirror or prism; wherein thesecond reference light reflects off of the mirror, reflects off of thesemi-transparent mirror or prism, and is received by the second camera;wherein the second sample light wave light reflects off of a secondsample, passes through the semi-transparent mirror or prism, and isreceived by the second camera; and wherein the second camera ispositioned to detect interference between the second reference lightwave and the second sample light wave.
 4. The eye examination apparatusof claim 3, wherein the components for interferometry further comprise:a first 2D MEMS (Microelectromechanical) mirror for beam steering thefirst sample wave and a first lens to condense the first sample waveinto a converging beam at the first sample; and a second 2D MEMS mirrorfor beam steering the second sample wave and a second lens to condensethe second sample wave into a converging beam at the second sample. 5.The eye examination apparatus of claim 1, wherein: the at least onedisplay comprises a first display positioned to be viewable through thefirst eye opening and a second display positioned to be viewable throughthe second eye opening; the first camera is positioned to acquireophthalmic images through the first eye opening via line of sightthrough the semi-transparent mirror or prism, and the first display isviewable through the first eye opening via reflection off of thesemi-transparent mirror or prism; and the second camera is positioned toacquire ophthalmic images through the second eye opening via line ofsight through the semi-transparent mirror or prism, and the seconddisplay is viewable through the second eye opening via reflection off ofthe semi-transparent mirror or prism.
 6. The eye examination apparatusof claim 1, wherein the at least one display is orthogonal to the firstand second cameras, and the semi-transparent mirror or prism is asemi-transparent mirror oriented at 45-degree angle relative to the atleast one display and the first and second cameras to facilitate thereflections.
 7. The eye examination apparatus of claim 1, furthercomprising: a first light emitter and at least one first condenser lensconfigured to render a divergent beam from the first light emitter intoa converging beam for funduscopy involving image capturing by the firstcamera; and a second light emitter and at least one second condenserlens configured to render a divergent beam from the second light emitterinto a converging beam for funduscopy involving image capturing by thesecond camera.
 8. The eye examination apparatus of claim 2, furthercomprising a refraction apparatus for refraction eye examination.
 9. Theeye examination apparatus of claim 8, wherein the refraction apparatusis selectively attachable to the eye examination apparatus.
 10. The eyeexamination apparatus of claim 2, comprising: adjustable lenses for thefirst eye opening and the second eye opening.
 11. The eye examinationapparatus of claim 2, further comprising at least one occluder.
 12. Theeye examination apparatus of claim 11, wherein the at least one occludercomprises a pair of occluders each having a plurality of pinholesconfigured to eliminate disorganized refracted light arrays which causeblurred vision in non-neurological eye conditions.
 13. The eyeexamination apparatus of claim 1, wherein the first eye opening and thesecond eye opening are separate openings.
 14. The eye examinationapparatus of claim 1, further comprising a headband for securing the eyeexamination apparatus to the user.
 15. The eye examination apparatus ofclaim 1, further comprising a helmet for securing the eye examinationapparatus to the user.
 16. An eye examination apparatus, comprising: abody having a first eye opening and a second eye opening for a user tosee into the eye examination apparatus using two eyes; a first cameracoupled to the body and positioned to acquire ophthalmic images throughthe first eye opening; a second camera coupled to the body andpositioned to acquire ophthalmic images through the second eye opening;at least one display coupled to the body and positioned to be viewablethrough the first eye opening and the second eye opening; wherein thefirst camera is part of a first sensor module and the second camera ispart of a second sensor module.
 17. The eye examination apparatus ofclaim 16, wherein: the first sensor module comprises a first laseremitter positioned to emit a laser through the first eye opening; andthe second sensor module comprises a second laser emitter positioned toemit a laser through the second eye opening.
 18. The eye examinationapparatus of claim 16, wherein: the first sensor module comprises afirst infrared projector positioned to project infrared light throughthe first eye opening, and a first infrared sensor positioned to receiveinfrared light from the first eye opening; and the second sensor modulecomprises a second infrared projector positioned to project infraredlight through the second eye opening, and a second infrared sensorpositioned to receive infrared light from the second eye opening. 19.The eye examination apparatus of claim 16, further comprising: aprocessing unit for controlling the first sensor module, the secondsensor module, and the at least one display.
 20. The eye examinationapparatus of claim 19, further comprising: at least one external sensorconfigured to sense an environment external to the eye examinationapparatus; wherein the processing unit controls the at least one displaybased on the at least one external sensor.
 21. The eye examinationapparatus of claim 20, wherein the at least one external sensorcomprises a pair of external cameras configured to capture theenvironment external to the eye examination apparatus, and theprocessing unit generates images for the at least one display using thepair of external cameras.